Amphetamine Orally Disintegrating Tablets

Product (Manufacturer) Formulation Approximate Duration of Effect Available Strengths Dosing Considerations Methylphenidate         Ritalin® or generic (Novartis and others) Immediate-release tablets* 3–4 hours 5, 10, 20 mg Provides flexibility for initial dose titration Methylin™ Chewable or generic (Shionogi Pharma and others) Chewable tablet* 3–4 hours 2.5, 5, 10 mg Contains phenylalanine Methylin™ Liquid or generic (Shionogi Pharma and others) Oral solution 3–4 hours 5 mg/5 mL and 10 mg/5 mL Grape-flavored solution; store at room temperature Metadate ER® or generic (UCB, Inc. and others) Extended-release tablet* 6–8 hours 10, 20 mg Swallow whole; do not break, crush, or chew Methylin ER™ (Shionogi Pharma) Extended-release tablet* 6–8 hours 10, 20 mg Swallow whole; do not break, crush, or chew Metadate CD® (UCB, Inc.) Diffucaps capsule with 30% immediate-release beads and 70% delayed-release beads* 8–10 hours 10, 20, 30, 40, 50, 60 mg Capsule may be opened and beads swallowed whole with applesauce Ritalin LA® (Novartis) Capsule with Spheroidal Oral Drug Absorption System (SODAS) technology; 50% immediate-release beads and 50% delayed-release (2nd peak 4 hrs later)* 8–10 hours 10, 20, 30, 40, 60 mg Capsule may be opened and beads swallowed whole with applesauce Do not give with antacids or acid suppressants Aptensio XR™ (Rhodes Pharmaceutical) Capsule with multilayer beads; 40% of dose in the immediate release layer and 60% in the extended-release layer (2nd peak at 7–8 hrs) 12 hours 10, 15, 20, 30, 40, 50, 60 mg Capsule may be opened and beads swallowed whole with applesauce Concerta® or generic (McNeil Pediatrics and others) Tablet with OROS osmotic pump technology; biphasic release with initial peak at 1 hr (20% of dose) and gradual release over 9 hrs 12 hours 18, 27, 36, 54 mg Must be swallowed whole; non-absorbable shell may be passed in stool Daytrana® (Noven Therapeutics) Transdermal patch with drug dispersed in adhesive layer; applied daily 12 hours with 9 hour wear time 10, 15, 20, 30 mg The time worn can be varied to control the duration of action; monitor for skin sensitization. Discard patches appropriately Quillivant XR™ (Pfizer) Extended-release oral suspension; 20% of the dose is immediate-release and 80% extended-release 12–13 hours 25 mg/5 mL Fruit-flavored; may be taken with or without food. Shake bottle for at least 10 seconds before preparing the dose. May be stored at room temperature Dexmethylphenidate Focalin® or generic (Novartis and others) Immediate-release tablets* 4–6 hours 2.5, 5, 10 mg Active isomer; give approx. ½ methylphenidate dose Focalin XR® or generic (Novartis and others) Capsule with SODAS technology; 50% of the beads contained in the capsule are immediate-release and 50% are delayed-release* 12 hours 5, 10, 15, 20, 25, 30, 35, 40 mg Capsule may be opened and beads swallowed whole with applesauce Do not give with antacids or acid suppressants Amphetamine Adzenys XR-ODT™ (Neo Therapeutics) Extended-release orally disintegrating tablets: 50% immediate-release and 50% delayed-release particles 10–12 hours 3.1, 6.3, 9.4, 12.5, 15.7, 18.8 mg Allow tablet to dissolve in saliva; do not crush or chew Dyanavel XR (Tris) Extended-release oral solution 13 hours 2.5 mg/mL Bubblegum flavor; may be taken with or without food. Shake bottle before preparing the dose. May be stored at room temperature. Dextroamphetamine Dextroamphetamine (various manufacturers) Immediate-release tablets or capsules 3–6 hours 2.5, 5, 7.5, 10, 15, 20, 30 mg Provides flexibility during initial titration ProCentra® and generic (Independence Pharmaceuticals and others) Oral solution 3–6 hours 5 mg/5 mL Colorless, bubble-gum flavor. Store at room temperature Mixed Amphetamine Salts Adderall® or generic (Teva and others) Immediate-release tablet 4–6 hours 5, 7.5, 10, 12.5, 15, 20, 30 mg   Adderall® XR or generic (Teva and others) Capsule with Micotrol delivery system: 50% immediate-release and 50% delayed-release beads* 10–12 hours 5, 10, 15, 20, 25, 30 mg Capsule may be opened and beads swallowed whole with applesauce Racemic Amphetamine Sulfate Evekeo (Arbor) Extended-release tablets 10 hours 5, 10 mg Also FDA approved for the treatment of narcolepsy and short-term treatment of obesity Lisdexamfetamine Vyvanse® (Shire) Capsule containing lisdexamfetamine (dextroamphetamine linked to l-lysine); peaks in 3.5 hrs* 10–13 hours 10, 20, 30, 40, 50, 60, 70 mg Capsule may be opened and contents dissolved in water, yogurt, or orange juice; use immediately after dissolving Atomoxetine Strattera® (Lilly) Capsule* 24 hours 10, 18, 25, 40, 60, 80, 100 mg Selective norepinephrine inhibitor; may take several weeks to achieve full effect Swallow capsule whole; powder is irritating Clonidine Catapres® or generic (Boehringer Ingelheim and others) Immediate-release tablets 3–6 hours (wide interpatient variability) 0.1, 0.2, 0.3 mg Sedating, typically initiated at bedtime; increase weekly by adding morning and then mid-day doses; can be made into an extemporaneous oral liquid formulation Catapres-TTS® or generic (Boehringer Ingelheim and others) Transdermal patch, applied weekly 5–7 days 0.1, 0.2, 0.3 mg/24 hours Potential for skin irritation; if patch loosens, cover with adhesive overlay. Cutting patches to provide a lower dose is not recommended. Discard patches appropriately Kapvay® (Concordia Pharmaceuticals) Extended-release tablets 12 hours 0.1, 0.2 mg Swallow tablet whole; typically dosed twice daily Guanfacine Tenex® or generic (Promius Pharma and others) Immediate-release tablets 6–12 hours 1, 2 mg   Intuniv™ or generic (Shire and others) Extended-release tablet 12–24 hours 1, 2, 3, 4 mg Swallow tablet whole; a high-fat meal may increase absorption and lead to toxicity
Source: Amphetamine Orally Disintegrating Tablets